RIP3 activator 1

RIP3 activator 1 (compound C8) is a potent RIP3 activator. RIP3 activator 1 inhibits cell growth. RIP3 activator 1 induces necroptosis through the RIP3/p62/Keap1 signaling pathway. RIP3 activator 1 increases the protein expression of p-MLKL. RIP3 activator 1 induces autophagy. RIP3 activator 1 increases accumulation of LC3-II and p62 protein expression[1].

Product Specifications

CAS Number

[1456899-52-7]

UNSPSC

12352211

Target

Autophagy; Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rip3-activator-1.html

Smiles

O[C@@H]1[C@@H](N)CO[C@H]1COCC(N=N2)=CN2CCCCCCCCCCCCCCCCCC

Molecular Formula

C26H50N4O3

Molecular Weight

466.70

References & Citations

[1]Liu X, et al. The RIP3 activator C8 regulates the autophagy flux mediated by p62 and promotes the immunogenic form of cell death in human gastric cancer cells. Bioorg Chem. 2024 Nov 3;153:107937.