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GEA 857

GEA 857 is a structural analog of the Serotonin uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases[1].

Product Specifications

CAS Number

120493-42-7

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gea-857.html

Smiles

N[C@@H](C(C)C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O

Molecular Formula

C15H22ClNO2

Molecular Weight

283.79

References & Citations

[1]Ögren, et al. GEA 857, A Putative Blocker of Potassium Conductance, Enhances Muscarinic Agonist‐Evoked Responses: Dissociation from an Action on 5‐HT Mechanisms. Pharmacology & toxicology 71.2 (1992) : 112-119.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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