Anemoside A3-methyl 6-aminohexanoate

Anemoside A3-methyl 6-aminohexanoate (Compound A3-6) is a derivative of Pulchinenoside C (Anemoside B4) (HY-N0205) . Anemoside A3-methyl 6-aminohexanoate inhibits pyruvate carboxylase (PC) with an IC50 of 0.058 μM, reprograms macrophage function, and alleviates DSS-induced colitis through inhibition of the NF-κB and NLRP3 inflammasome pathway. Anemoside A3-methyl 6-aminohexanoate exhibits a moderate in vivo pharmacokinetic characters compared with Anemoside B4[1].

Product Specifications

CAS Number

[2919975-48-5]

UNSPSC

12352005

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anemoside-a3-methyl-6-aminohexanoate.html

Concentration

10mM

Purity

98.62

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C=C(C)[C@@H]1CC[C@]2(C(NCCCCCC(OC)=O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@](C)(CO)[C@@H](O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H](C)[C@H](O)[C@@H](O)[C@H]7O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H]

Molecular Formula

C48H79NO13

Molecular Weight

878.14

References & Citations

[1]Lv L, et al., Discovery of a New Anti-Inflammatory Agent from Anemoside B4 Derivatives and Its Therapeutic Effect on Colitis by Targeting Pyruvate Carboxylase. J Med Chem. 2024 May 9;67 (9) :7385-7405.