16-Azidohexadecanoic acid

16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism[1][2]. 16-Azidohexadecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

[1]J Balintová, et al. Antibody-nucleotide conjugate as a substrate for DNA polymerases. Chem Sci. 2018 Jul 24;9(35):7122-7125. |[2]Alexander J Pérez, et al. ω-Azido fatty acids as probes to detect fatty acid biosynthesis, degradation, and modification. J Lipid Res. 2014 Sep;55(9):1897-901.