Otilonium-d4 (bromide)

Otilonium-d4 (bromide) is deuterium labeled Otilonium (bromide) .

Product Specifications

Product Name Alternative

Octylonium-d4 (bromide) ; SP63-d4 (bromide)

UNSPSC

12352005

Target

Isotope-Labeled Compounds; mAChR

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(OC([2H])([2H])C([2H])([2H])[N+](CC)(CC)C)C1=CC=C(NC(C2=CC=CC=C2OCCCCCCCC)=O)C=C1.[Br-]

Molecular Formula

C29H39D4BrN2O4

Molecular Weight

567.59

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Battaglia, G., et al., Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther, 1998. 12 (10) : p. 1003-10.|[3]Clave, P., et al., Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Aliment Pharmacol Ther, 2011. 34 (4) : p. 432-42.|[4]Gandia, L., et al., Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol, 1996. 117 (3) : p. 463-470.|[5]Lindqvist, S., et al., The colon-selective spasmolytic otilonium bromide inhibits muscarinic M (3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol, 2002. 137 (7) : p. 1134-42.