TAK-632
TAK-632 is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively.
Product Specifications
CAS Number
[1228591-30-7]
UNSPSC
12352005
Hazard Statement
H302
Target
Aurora Kinase; Raf
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TAK-632.html
Purity
99.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(OC2=CC=C3N=C(NC(C4CC4)=O)SC3=C2C#N)=CC=C1F)CC5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C27H18F4N4O3S
Molecular Weight
554.52
Precautions
H302
References & Citations
[1]Okaniwa M, et al. Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. J Med Chem. 2013 Aug 22;56 (16) :6478-94.|[2]Nakamura A, et al. Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma. Cancer Res. 2013 Oct 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora B; B-Raf; C-Raf
Available Sizes
Curated Selection
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