BI-6901

BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0) . BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].

Product Specifications

CAS Number

[2040401-92-9]

Product Name Alternative

TC-1734; ACD3480

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bi-6901.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 160 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CC2=C1C=CN2)(N[C@@H](C(N3CCC(C)CC3)=O)CCN4C(C#N)=CC=C4)=O

Molecular Formula

C23H27N5O3S

Molecular Weight

453.56

References & Citations

[1]Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26 (21) :5277-5283.