Nelarabine

Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL) [1].

Product Specifications

CAS Number

[121032-29-9]

Product Name Alternative

506U78; GW 506U78; Nelzarabine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Nelarabine.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C=NC3=C(OC)N=C(N)N=C23)O1

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Lonetti A, et al. Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway. J Hematol Oncol. 2016 Oct 24;9 (1) :114.|[2]Wang H, et al. Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia. Blood, 2020, 136: 26.