Nelarabine
Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL) [1].
Product Specifications
CAS Number
121032-29-9
Product Name Alternative
506U78; GW 506U78; Nelzarabine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nelarabine.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C=NC3=C(OC)N=C(N)N=C23)O1
Molecular Formula
C11H15N5O5
Molecular Weight
297.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Lonetti A, et al. Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway. J Hematol Oncol. 2016 Oct 24;9 (1) :114.|[2]Wang H, et al. Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia. Blood, 2020, 136: 26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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