DUPA

DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in agent conjugate to selectively deliver cytotoxic agents to prostate cancer cells[1][2].

Product Specifications

CAS Number

[302941-52-2]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dupa.html

Purity

98.0

Solubility

DMSO : ≥ 300 mg/mL|H2O : ≥ 150 mg/mL

Smiles

O=C(N[C@](CCC(O)=O)([H])C(O)=O)N[C@](CCC(O)=O)([H])C(O)=O

Molecular Formula

C11H16N2O9

Molecular Weight

320.25

Precautions

H315, H319, H335

References & Citations

[1]Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21 (10) :968-80.|[2]Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting. J Med Chem. 2015 Apr 9;58 (7) :3094-103.