L-659837

L-659837 is a NK2 receptor antagonist, and can antagonize GR 64349 (HY-P1278) -induced contraction. L-659837 can be used for study of urinary bladder disorders[1].

Product Specifications

CAS Number

[125989-10-8]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-659837.html

Smiles

CC(C)C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC2=CC=CC=C21)C(N[C@H]3CC4=CC=CC=C4)=O)=O)=O)=O)[N@]5CC[C@H](C5=O)NC3=O

Molecular Formula

C40H52N8O7S

Molecular Weight

788.96

References & Citations

[1]Palea S, et al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996;277 (2) :700-705.