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CDC25B-IN-1

CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase[1].

Product Specifications

CAS Number

[2374831-10-2]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdc25b-in-1.html

Purity

98.12

Solubility

DMSO : 100 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic)

Smiles

COC1=CC2=CC=CC=C2C(NC3=CC=CC(C(OCC)=O)=C3)=C1

Molecular Formula

C20H19NO3

Molecular Weight

321.37

References & Citations

[1]Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem. 2019 Aug 8;62 (15) :7089-7110.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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