Clomazone

Clomazone is a broad spectrum herbicide, mainly used to control annual broadleaf weeds and grass weeds in various crops such as rice, soybeans, and peanuts. Clomazone inhibits carotenoid biosynthesis, and treated plants show typical "albinism" symptoms due to the destruction of chloroplast membrane structure leading to chlorophyll degradation. Clomazone exhibits multiple toxic effects on non-target organisms, including aquatic lethality, developmental malformations, liver damage, mitochondrial dysfunction, and hematotoxicity[1][2][3].

Product Specifications

CAS Number

[81777-89-1]

UNSPSC

12352005

Hazard Statement

H302, H332, H400, H410

Target

Herbicide

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/clomazone.html

Concentration

10mM

Purity

99.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CC2=CC=CC=C2Cl)OCC1(C)C

Molecular Formula

C12H14ClNO2

Molecular Weight

239.70

Precautions

H302, H332, H400, H410

References & Citations

[1]Stevanovic M, et al. Toxicity of clomazone and its formulations to zebrafish embryos (Danio rerio) . Aquat Toxicol. 2017 Jul;188:54-63. |[2]Dos Santos Silva HP, et al. Ametryn and Clomazone Disrupt Mitochondrial Bioenergetics in Rat Liver: Evidence for Inhibition of Complexes I and II and ATP Synthase. Toxics. 2025 Sep 16;13 (9) :784. |[3]Tang HB, et al. Herbicide clomazone induced hematotoxicity and hepatic compensatory responses in the invasive turtle, Trachemys scripta elegans. Aquat Toxicol. 2025 Sep;286:107470.