DYR684
Product Specifications
CAS Number
3038487-48-5
UNSPSC Description
DYR684 is a PROTAC of the protein kinases DYRK1A. DYR684 promotes fast, efficient, potent, and selective degradation of DYRK1A in cell-based assays. (Pink: ligand for target protein (HY-168195); Black: linker (HY-168200); Blue: ligand for E3 ligase (HY-168198))[1].
Target Antigen
DYRK; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dyr684.html
Smiles
O=C(C(N(C(C1=C2C=CC=C1NCC3=CN(C4CCN(C(C5CCN(C6=NC=C(C#CCN7CCN(C8=CC=C(N9C(C)=NC%10=CC=C(C%11=CC(N)=NC=C%11)N=C%109)C=C8F)CC7)C=C6)CC5)=O)CC4)N=C3)=O)C2=O)CC%12)NC%12=O
Molecular Weight
1064.18
References & Citations
[1]Wilms G, et, al. Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B. J Med Chem. 2024 Oct 10;67(19):17259-17289.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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