Glucokinase activator 3

Glucokinase activator 3 is an orally active Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 inhibits hERG channel and sodium channel in patch clamp assays. Glucokinase activator 3 exhibits high efficacy in reducing blood glucose in diet-induced obese (DIO) mice. Glucokinase activator 3 has the potential for the research of type 2 diabetes[1].

Product Specifications

CAS Number

[1001417-92-0]

UNSPSC

12352005

Target

Glucokinase; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glucokinase-activator-3.html

Concentration

10mM

Purity

98.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC(CP(OCC)(OCC)=O)=CS1)C2=CC(OC3=CC=C(S(=O)(C)=O)C=C3)=CC(O[C@@H](C)COC)=C2

Molecular Formula

C26H33N2O9PS2

Molecular Weight

612.65

References & Citations

[1]Shi Y, et al. Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3- (3- ((5- (Azetidine-1-carbonyl) pyrazin-2-yl) oxy) -5-isopropoxybenzamido) -1H-pyrazol-1-yl) methyl) phosphonate (BMS-820132) . J Med Chem. 2022, 65 (5) :4291-4317.