Mefenamic acid-13C6
Mefenamic acid-13C6 is the 13C-labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
Product Specifications
CAS Number
1325559-19-0
UNSPSC
12352005
Hazard Statement
H315-H318
Target
COX; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mefenamic-acid-13c6.html
Solubility
10 mM in DMSO
Smiles
OC([13C]([13CH]=[13CH][13CH]=[13CH]1)=[13C]1NC2=C(C(C)=CC=C2)C)=O
Molecular Formula
C9 13C6H15NO2
Molecular Weight
247.24
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2) :479-84.|[3]Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz) . 2016 Sep;17 (3) :219-25.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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