NV03
NV03 is a potent and selective antagonist of Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) -H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 is also a ligand for E3 ligase. NV03 can be studied in anticancer research[1][2].
Product Specifications
CAS Number
2448341-58-8
UNSPSC
12352005
Target
Histone Methyltransferase; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nv03.html
Purity
99.77
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(CC(NCCCN(CC)CC)=O)N=C(C)N2C1=C(C)C3=C2C=CS3
Molecular Formula
C19H27N5O2S
Molecular Weight
389.51
References & Citations
[1]Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23 (9) :930-940.|[2]Wuxiang Mao and Matt Soellner, Small molecule degraders of c-src kinase. WO2024123819A2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
UHRF1
Available Sizes
Frequently Asked Questions
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