NV03

NV03 is a potent and selective antagonist of Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) -H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 is also a ligand for E3 ligase. NV03 can be studied in anticancer research[1][2].

Product Specifications

CAS Number

[2448341-58-8]

UNSPSC

12352005

Target

Histone Methyltransferase; Ligands for E3 Ligase

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nv03.html

Purity

99.77

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(CC(NCCCN(CC)CC)=O)N=C(C)N2C1=C(C)C3=C2C=CS3

Molecular Formula

C19H27N5O2S

Molecular Weight

389.51

References & Citations

[1]Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23 (9) :930-940.|[2]Wuxiang Mao and Matt Soellner, Small molecule degraders of c-src kinase. WO2024123819A2.