PKC-iota inhibitor 1

PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer[1][2][3].

Product Specifications

CAS Number

[2328094-11-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; PKC

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pkc-iota-inhibitor-1.html

Purity

99.60

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=C(C(NC2=CC=NC=C2)=O)C=C(C3=CC=CC(N4CCNCC4)=C3)C=N1

Molecular Formula

C21H22N6O

Molecular Weight

374.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Kwiatkowski J, et al. Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. ACS Med Chem Lett. 2019 Feb 15;10 (3) :318-323.|[2]Miyake Y, et al. Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis. Commun Biol. 2022 Jul 22;5 (1) :734.|[3]Tompkins E, et al. The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype. J Biol Chem. 2023 Oct;299 (10) :105209.