PKC-iota inhibitor 1
PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer[1][2][3].
Product Specifications
CAS Number
2328094-11-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; PKC
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pkc-iota-inhibitor-1.html
Purity
99.60
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=C(C(NC2=CC=NC=C2)=O)C=C(C3=CC=CC(N4CCNCC4)=C3)C=N1
Molecular Formula
C21H22N6O
Molecular Weight
374.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Kwiatkowski J, et al. Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. ACS Med Chem Lett. 2019 Feb 15;10 (3) :318-323.|[2]Miyake Y, et al. Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis. Commun Biol. 2022 Jul 22;5 (1) :734.|[3]Tompkins E, et al. The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype. J Biol Chem. 2023 Oct;299 (10) :105209.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKC-ι ℩
Available Sizes
Frequently Asked Questions
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