Lovastatin

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

Product Specifications

CAS Number

[75330-75-5]

Product Name Alternative

Mevinolin

UNSPSC

12352005

Hazard Statement

H351, H361

Target

Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Lovastatin.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@@H](C)CC)O[C@@H]1[C@@]([C@H]2CC[C@@H](OC3=O)C[C@H](C3)O)([H])C(C=C[C@@H]2C)=C[C@H](C)C1

Molecular Formula

C24H36O5

Molecular Weight

404.54

Precautions

H351, H361

References & Citations

[1]Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62 (15) :10J-15J.|[2]Kah J, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012 Sep;28 (3) :1077-83.|[3]Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73 (2) :437-48.|[4]Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2 (7) :517-26.|[5]Ifergan I, et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol. 2006 Jul;60 (1) :45-55.|[6]Chu W, et al. Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B. Exp Ther Med. 2016 Sep;12 (3) :1741-1749. |[7]Régrigny O, et al. Effect of lovastatin on cerebral circulation in spontaneously hypertensive rats. Hypertension. 2000 May;35 (5) :1105-10.