Lovastatin
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
Product Specifications
CAS Number
75330-75-5
Product Name Alternative
Mevinolin
UNSPSC
12352005
Hazard Statement
H351, H361
Target
Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Lovastatin.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@@H](C)CC)O[C@@H]1[C@@]([C@H]2CC[C@@H](OC3=O)C[C@H](C3)O)([H])C(C=C[C@@H]2C)=C[C@H](C)C1
Molecular Formula
C24H36O5
Molecular Weight
404.54
Precautions
H351, H361
References & Citations
[1]Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62 (15) :10J-15J.|[2]Kah J, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012 Sep;28 (3) :1077-83.|[3]Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73 (2) :437-48.|[4]Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2 (7) :517-26.|[5]Ifergan I, et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol. 2006 Jul;60 (1) :45-55.|[6]Chu W, et al. Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B. Exp Ther Med. 2016 Sep;12 (3) :1741-1749. |[7]Régrigny O, et al. Effect of lovastatin on cerebral circulation in spontaneously hypertensive rats. Hypertension. 2000 May;35 (5) :1105-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
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