MARK4 inhibitor 1

MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis[1].

Product Specifications

CAS Number

[2271081-58-2]

Product Name Alternative

AZD-3355 (hydrochloride),AM152 (sodium),AZD-3355 (napadisylate)

UNSPSC

12352005

Target

AMPK; Apoptosis; MARK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mark4-inhibitor-1.html

Purity

98.29

Solubility

DMSO : 5 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

O=C(C1=CN(CC2=CC=C(OC)C=C2)N=N1)N/N=C3C(NC4=C/3C=CC=C4C)=O

Molecular Formula

C20H18N6O3

Molecular Weight

390.40

References & Citations

[1]Aneja B, et al. Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem. 2019 Feb 1;163:840-852.