NPC-15437 (dihydrochloride)
NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation[1][2][3].
Product Specifications
CAS Number
141774-20-1
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/npc-15437-dihydrochloride.html
Purity
98.66
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl
Molecular Formula
C25H52Cl2N4O2
Molecular Weight
511.61
References & Citations
[1]Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220 (1) :107-10. |[2]Sullivan JP, et al. 2,6-Diamino-N- ([1- (1-oxotridecyl) -2-piperidinyl] methyl) hexanamide (NPC 15437) : a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Maheux, J., et al. Pharmacol. 1992 Jan;41 (1) :38-44. |[3]Modulation of Nur77 expression by dopaminergic drug is altered by a MEK pathway inhibitor in vivo. The FASEB Journal, 20: A684-A685.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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