NPC-15437 (dihydrochloride)

NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation[1][2][3].

Product Specifications

CAS Number

[141774-20-1]

UNSPSC

12352005

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/npc-15437-dihydrochloride.html

Purity

98.66

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl

Molecular Formula

C25H52Cl2N4O2

Molecular Weight

511.61

References & Citations

[1]Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220 (1) :107-10. |[2]Sullivan JP, et al. 2,6-Diamino-N- ([1- (1-oxotridecyl) -2-piperidinyl] methyl) hexanamide (NPC 15437) : a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Maheux, J., et al. Pharmacol. 1992 Jan;41 (1) :38-44. |[3]Modulation of Nur77 expression by dopaminergic drug is altered by a MEK pathway inhibitor in vivo. The FASEB Journal, 20: A684-A685.