6-O-Isobutyrylbritannilactone

6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318) -induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models[1].

Product Specifications

CAS Number

[1259933-02-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; Epigenetic Reader Domain; ERK; PI3K

Type

Natural Products

Related Pathways

Epigenetics; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-o-isobutyrylbritannilactone.html

Solubility

10 mM in DMSO

Smiles

CC(C)C(O[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCO)=O

Molecular Formula

C19H28O5

Molecular Weight

336.42

Precautions

P264-P270-P330-P501

References & Citations

[1]Jang DK, et al. Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models. Molecules. 2020 Aug 26;25 (17) :3887.