Gavestinel (sodium salt)

Gavestinel (GV 150526A) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke[1].

Product Specifications

CAS Number

[153436-38-5]

Product Name Alternative

GV 150526A

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gavestinel-sodium-salt.html

Purity

98.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC=C1)/C=C/C2=C(C(O[Na])=O)NC3=CC(Cl)=CC(Cl)=C23

Molecular Formula

C18H11Cl2N2NaO3

Molecular Weight

397.19

References & Citations

[1]Fabio RD, et, al. Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J Med Chem. 1997 Mar 14;40 (6) :841-50.