Mcl-1L Cytoplasmic Domain Human Recombinant

<strong>Mcl-1L Cytoplasmic Domain Human Recombinant </strong>_x000D_ <strong>Catalog number:</strong> B2016818_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 36 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Bcl-2-like Protein 3, EAT/Mcl-1, Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Mcl-1 Long Isoform_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Kim JH, Bae J. MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis PLoS One. 2013 Nov 18;8(11):e79626._x000D_ 2: Fukumoto T, Iwasaki T, Okada T, Hashimoto T, Moon Y, Sakaguchi M, Fukami Y, Nishigori C, Oka M. High expression of Mcl-1L via the MEK-ERK-phospho-STAT3 (Ser727) pathway protects melanocytes and melanoma from UVB-induced apoptosis Genes Cells. 2016 Feb;21(2):185-99._x000D_ 3: Kim JH, Sim SH, Ha HJ, Ko JJ, Lee K, Bae J. MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death FEBS Lett. 2009 Sep 3;583(17):2758-64._x000D_ 4: Morciano G, Giorgi C, Balestra D, Marchi S, Perrone D, Pinotti M, Pinton P. Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death Mol Biol Cell. 2016 Jan 1;27(1):20-34._x000D_ 5: Han J, Goldstein LA, Gastman BR, Froelich CJ, Yin XM, Rabinowich H. Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events J Biol Chem. 2004 May 21;279(21):22020-9._x000D_ 6: Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K. MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair Biochem Biophys Res Commun. 2010 Jan 1;391(1):492-7._x000D_ 7: Legartova S, Krejci J, Harnicarova A, Hajek R, Kozubek S, Bartova E. Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma Neoplasma. 2009;56(5):404-13._x000D_ 8: Buron N, Porceddu M, Brabant M, Desgué D, Racoeur C, Lassalle M, Péchoux C, Rustin P, Jacotot E, Borgne-Sanchez A. Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization PLoS One. 2010 Mar 31;5(3):e9924._x000D_ 9: Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A. MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8 Cell Tissue Res. 2017 May;368(2):325-335._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33052877">10: Li Y, Gao X, Wei C, Guo R, Xu H, Bai Z, Zhou J, Zhu J, Wang W, Wu Y, Li J, Zhang Z, Xie X. Modification of Mcl-1 alternative splicing induces apoptosis and suppresses tumor proliferation in gastric cancer Aging (Albany NY). 2020 Oct 14;12(19):19293-19315. </a>_x000D_ _x000D_ <strong>Products Related to Mcl-1L Cytoplasmic Domain Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>