SIRT6 activator 2
SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases[1].
Product Specifications
CAS Number
2867630-96-2
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sirt6-activator-2.html
Smiles
O=C1C(NC2=C(C=CC=C2)OC)=C(C1=O)N[C@H]3CC[C@@H](CC3)OC4=CC=C(C=C4)[N+]([O-])=O
Molecular Formula
C23H23N3O6
Molecular Weight
437.45
References & Citations
[1]Nguyen LH, et al. Discovery of N-Aryl-N'-[4- (aryloxy) cyclohexyl]squaramide-Based Inhibitors of LXR/SREBP-1c Signaling Pathway Ameliorating Steatotic Liver Disease: Navigating the Role of SIRT6 Activation. J Med Chem. 2024 Oct 10;67 (19) :17608-17628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT6
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