GW274150
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM) . GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS) . GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2].
Product Specifications
CAS Number
210354-22-6
UNSPSC
12352211
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GW274150.html
Concentration
10mM
Purity
98.42
Solubility
H2O : ≥ 62 mg/mL
Smiles
N[C@@H](CCSCCNC(C)=N)C(O)=O
Molecular Formula
C8H17N3O2S
Molecular Weight
219.30
References & Citations
[1]Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145 (3) :301-12.|[2]Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141 (6) :979-87. Epub 2004 Feb|[3]Broom L, et al. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease.Free Radic Biol Med. 2011 Mar 1;50 (5) :633-40.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
INOS
Available Sizes
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