5-Hydroxydiclofenac
5-Hydroxydiclofenac is a major metabolite of Diclofenac. 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes[1].
Product Specifications
CAS Number
69002-84-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H372, H410
Target
Apoptosis; Drug Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-hydroxydiclofenac.html
Purity
98.0
Smiles
O=C(CC1=CC(O)=CC=C1NC2=C(Cl)C=CC=C2Cl)O
Molecular Formula
C14H11Cl2NO3
Molecular Weight
312.15
Precautions
H302, H315, H319, H335, H372, H410
References & Citations
[1]A Mancy, et al. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38 (43) :14264-70. |[2]M José Gómez-Lechón, et al. Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem Pharmacol. 2003 Dec 1;66 (11) :2155-67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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