5-Hydroxydiclofenac

5-Hydroxydiclofenac is a major metabolite of Diclofenac (HY-15036) . 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes[1].

Product Specifications

CAS Number

[69002-84-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H372, H410

Target

Apoptosis; Drug Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-hydroxydiclofenac.html

Purity

98.0

Smiles

O=C(CC1=CC(O)=CC=C1NC2=C(Cl)C=CC=C2Cl)O

Molecular Formula

C14H11Cl2NO3

Molecular Weight

312.15

Precautions

H302, H315, H319, H335, H372, H410

References & Citations

[1]A Mancy, et al. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38 (43) :14264-70. |[2]M José Gómez-Lechón, et al. Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem Pharmacol. 2003 Dec 1;66 (11) :2155-67.