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CXCL14/BRAK, Human

CXCL14 (also known as breast and kidney-expressed chemokine (BRAK) ), as a non-ELR CXC chemokine. CXCL14 displays chemotactic activity for monocytes but not for B and T cells. CXCL14 is involved in cancer, immune responses, and epithelial cell proliferation and migration. CXCL14 is a potent inhibitor of angiogenesis, and also shows antimicrobial activity[1][2]. CXCL14/BRAK Protein, Human is produced in E. coli, and consists of 77 amino acids (S35-E111) .

Product Specifications

Product Name Alternative

CXCL14/BRAK Protein, Human, Human, E. coli

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/cxcl14-brak-protein-human.html

Purity

98.0

Smiles

SKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSVSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE

Molecular Formula

9547 (Gene_ID) O95715 (S35-E111) (Accession)

Molecular Weight

Approximately 13-15 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Arezoo Gowhari Shabgah, et al. Chemokine CXCL14; a double-edged sword in cancer development. Int Immunopharmacol. 2021 Aug;97:107681.|[2]Joseph A Westrich, et al. The multifarious roles of the chemokine CXCL14 in cancer progression and immune responses. Mol Carcinog. 2020 Jul;59 (7) :794-806.|[3]Galina V Shurin, et al. Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo. J Immunol. 2005 May 1;174 (9) :5490-8.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

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