Exicorilant
Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM[1]. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia[2].
Product Specifications
CAS Number
1781244-77-6
Product Name Alternative
CORT 125281
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/exicorilant.html
Purity
99.48
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C[C@]1([H])CCN(S(=O)(C5=NN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6
Molecular Formula
C26H23F4N7O3S
Molecular Weight
589.56
References & Citations
[1]Hunt HJ, et al. Identification of the Clinical Candidate (R) - (1- (4-Fluorophenyl) -6- ((1-methyl-1H-pyrazol-4-yl) sulfonyl) -4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl) (4- (trifluoromethyl) pyridin-2-yl) methanone (CORT125134) : A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60 (8) :3405-3421.|[2]Kroon J, et al. Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice. Endocrinology. 2018 Jan 1;159 (1) :535-546.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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