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Alsevalimab

Alsevalimab is a humanized, afucosylated IgG1 monoclonal antibody against B7-H4. Alsevalimab blocks the binding of the B7-H4 protein to the receptors on the surface of T cells, reversing the immunosuppressive state in the tumor microenvironment, thereby activating the killing effect of T cells on cancer cells. Alsevalimab can be used in combination with Pembrolizumab , and shows good safety profiles[1].

Product Specifications

CAS Number

2254029-91-7

UNSPSC

12352203

Target

CD276/B7-H3

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alsevalimab.html

Purity

95.00

Solubility

10 mM in DMSO

Smiles

[Alsevalimab]

Molecular Weight

(144.74 kDa)

References & Citations

[1]Phipps M, Falchook GS. B7 Homolog 4 (B7-H4) -Directed Agents in Oncology Clinical Trials: A Review. J Immunother Precis Oncol. 2025 Apr 10;8 (2) :153-160.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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