ODN M362
Product Specifications
UNSPSC Description
ODN M362, a class C oligodeoxynucleotide, is a TLR-9 agonist and can be used as a vaccine adjuvant. ODN M362 induces cancer cell apoptosis[1][2].
Target Antigen
Apoptosis; Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/odn-m362.html
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[DNA, d(P-thio)(T-C-G-T-C-G-T-C-G-T-T-C-G-A-A-C-G-A-C-G-T-T-G-A-T)]
Molecular Weight
8049.50
References & Citations
[1]Babaer D, et al. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel). 2019 May 14;11(5):672.|[2]Zhang Y, et al. Phosphorothioate-modified CpG oligodeoxynucleotide (CpG ODN) induces apoptosis of human hepatocellular carcinoma cells independent of TLR9. Cancer Immunol Immunother. 2014 Apr;63(4):357-67.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150750/ODN-M362-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150750/ODN-M362-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
934655-87-5
Available Sizes
Curated Selection
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