MRT00033659
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM) . MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1].
Product Specifications
CAS Number
1401731-54-1
UNSPSC
12352005
Target
Casein Kinase; Checkpoint Kinase (Chk) ; Early 2 Factor (E2F) ; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrt00033659.html
Purity
99.77
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
CC1=NNC2=NC=C(C=C21)C3=CC=CC(NC(C)=O)=C3
Molecular Formula
C15H14N4O
Molecular Weight
266.30
References & Citations
[1]Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23 (20) :5578-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; CK1
Available Sizes
Frequently Asked Questions
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