MRT00033659

MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM) . MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1].

Product Specifications

CAS Number

[1401731-54-1]

UNSPSC

12352005

Target

Casein Kinase; Checkpoint Kinase (Chk) ; Early 2 Factor (E2F) ; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mrt00033659.html

Purity

99.77

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CC1=NNC2=NC=C(C=C21)C3=CC=CC(NC(C)=O)=C3

Molecular Formula

C15H14N4O

Molecular Weight

266.30

References & Citations

[1]Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23 (20) :5578-85.