EN4

EN4 is a covalent ligand that targets cysteine 171 (C171) of MYC. EN4 is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis[1].

Product Specifications

CAS Number

[1197824-15-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-Myc

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/en4.html

Purity

96.29

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC=C1OC2=CC=C(OCC)C=C2)C3=CC=C(CNC(C=C)=O)C=C3

Molecular Formula

C25H24N2O4

Molecular Weight

416.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Lydia Boike, et al. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28 (1) :4-13.e17.