PI3K/mTOR Inhibitor-4

PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR Inhibitor-4 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2361215-32-7]

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-mtor-inhibitor-4.html

Purity

97.04

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC1=CC=C(S(NC2=CC(C3=CC=C(OCC(N4C5=CC=C(OC)C=C5)=O)C4=C3)=CN=C2OC)(=O)=O)C=C1

Molecular Formula

C27H22FN3O6S

Molecular Weight

535.54

References & Citations

[1]Guoyi Yan, et al. Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3 (4H) -one derivatives as potent and orally active PI3K/mTOR dual inhibitors. Eur J Med Chem