Tamapin (TFA)
Tamapin TFA is a venom peptide, targeting to small conductance Ca (2+) -activated K (+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel) . Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) [1].
Product Specifications
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tamapin-tfa.html
Purity
98.79
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]1CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N3[C@H](C(N[C@H](C(N)=O)CC4=CC=C(O)C=C4)=O)CCC3)=O)C(C)C)=O)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CSSC[C@H](NC5=O)C(N[C@H]2CCCCN)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)=O)CSSC[C@H](NC1=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5CCC(O)=O)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)=O)CC6=CC=CC=C6.O=C(C(F)(F)F)O.[x]
Molecular Formula
C146H238N44O41S6.xC2HF3O2
Molecular Weight
3458.11 (free base)
References & Citations
[1]Pedarzani P, et al. Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J Biol Chem. 2002 Nov 29;277 (48) :46101-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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