BMS-566419
BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH) . Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection[1].
Product Specifications
CAS Number
566161-24-8
UNSPSC
12352005
Target
IMPDH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bms-566419.html
Purity
99.68
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(F)=C(C(NC(C)(C3=CN=C(N4CCN(CC)CC4)C=C3)C)=O)C=C2NC5=CC=CC=C15
Molecular Formula
C28H30FN5O2
Molecular Weight
487.57
References & Citations
[1]Watterson SH, et al. Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N- (2- (6- (4-ethylpiperazin-1-yl) pyridin-3-yl) propan-2-yl) -2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419) . J Med Chem. 2007;50 (15) :3730-3742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY430405 100 µg
ANR52 (ANKRD52) (NM_173595) Human Over-expression Lysate
Sign In for Pricing
View Details ![ZNF69 Mouse Monoclonal Antibody [Clone ID: OTI3D11]](https://cdn.genprice.uk/products/937/68dd18b9061270361e908299/imageurl/cf808235.webp)
CF808235 100 µg
ZNF69 Mouse Monoclonal Antibody [Clone ID: OTI3D11]
Sign In for Pricing
View Details 
BNC682652-500 1x 500 µL
B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 