BMS-566419
BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH) . Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection[1].
Product Specifications
CAS Number
566161-24-8
UNSPSC
12352005
Target
IMPDH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bms-566419.html
Purity
99.68
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(F)=C(C(NC(C)(C3=CN=C(N4CCN(CC)CC4)C=C3)C)=O)C=C2NC5=CC=CC=C15
Molecular Formula
C28H30FN5O2
Molecular Weight
487.57
References & Citations
[1]Watterson SH, et al. Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N- (2- (6- (4-ethylpiperazin-1-yl) pyridin-3-yl) propan-2-yl) -2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419) . J Med Chem. 2007;50 (15) :3730-3742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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