YM-I-26
YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of IL-1β and IL-10. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation[1].
Product Specifications
CAS Number
2585015-90-1
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ym-i-26.html
Smiles
O=S(C1=CC=C(CCN(CC2=C(OCCC)C=CC(Cl)=C2)C(CC3=CSC=C3)=O)C=C1)(N4CCOCC4)=O
Molecular Formula
C28H33ClN2O5S2
Molecular Weight
577.16
References & Citations
[1]Biby S, et al. Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome[J]. ACS Chemical Neuroscience, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-10
Frequently Asked Questions
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