N, N-Dimethylglycine

N, N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N, N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N, N-Dimethylglycine has antidepressant-like and surfactant effects[1][2][3].

Product Specifications

CAS Number

[1118-68-9]

Product Name Alternative

Dimethylglycine; DMG; N-Methylsarcosine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives; Endogenous Metabolite; iGluR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/N-Methylsarcosine.html

Concentration

10mM

Purity

98.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CN(C)C

Molecular Formula

C4H9NO2

Molecular Weight

103.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Hsieh CP, et al. N, N-dimethylglycine Protects Behavioral Disturbances and Synaptic Deficits Induced by Repeated Ketamine Exposure in Mice. Neuroscience. 2021 Sep 15;472:128-137.|[2]Bai K, et al. Dimethylglycine sodium salt protects against oxidative damage and mitochondrial dysfunction in the small intestines of mice. Int J Mol Med. 2019 May;43 (5) :2199-2211. |[3]Bai K, et al. Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice. PLoS One. 2016 May 12;11 (5) :e0155393.