Lactisole
Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].
Product Specifications
CAS Number
150436-68-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Taste Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lactisole.html
Purity
99.68
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)OC(C(O[Na])=O)C
Molecular Formula
C10H11NaO4
Molecular Weight
218.18
Precautions
H315, H319, H335
References & Citations
[1]Hamano K, et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. J Endocrinol. 2015 Jul;226 (1) :57-66.|[2]Schweiger K, et al. Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. Nutrients. 2020 Oct 14;12 (10) :3133.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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