Lactisole

Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].

Product Specifications

CAS Number

[150436-68-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Taste Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lactisole.html

Purity

99.68

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C=C1)OC(C(O[Na])=O)C

Molecular Formula

C10H11NaO4

Molecular Weight

218.18

Precautions

H315, H319, H335

References & Citations

[1]Hamano K, et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. J Endocrinol. 2015 Jul;226 (1) :57-66.|[2]Schweiger K, et al. Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. Nutrients. 2020 Oct 14;12 (10) :3133.