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Ethylmalonic acid

Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation[1][2][3][4].

Product Specifications

CAS Number

601-75-2

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Propanedioic_acid,_2-ethyl-.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(O)C(CC)C(O)=O

Molecular Formula

C5H8O4

Molecular Weight

132.11

Precautions

H315, H319, H335

References & Citations

[1]Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26 (2) :168-78.|[2]Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28 (5) :771-7.|[3]Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35 (2) :298-305.|[4]Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10 (5) :e0126606.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Available Sizes

Frequently Asked Questions

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