Ketoprofen

Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

Product Specifications

CAS Number

[22071-15-4]

Product Name Alternative

RP-19583

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Ketoprofen.html

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)C2=CC=CC(C(C(O)=O)C)=C2

Molecular Formula

C16H14O3

Molecular Weight

254.28

Precautions

H301, H315, H319, H335

References & Citations

[1]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7. |[2]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596. |[3]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.