Thiamine disulfide
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].
Product Specifications
CAS Number
67-16-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; HIV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thiamine-disulfide.html
Purity
99.54
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C/C(N(CC1=CN=C(C)N=C1N)C=O)=C(SS/C(CCO)=C(N(CC2=CN=C(C)N=C2N)C=O)\C)/CCO
Molecular Formula
C24H34N8O4S2
Molecular Weight
562.71
Precautions
H302, H315, H319, H335
References & Citations
[1]S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205 (1) :967-75.|[2]Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81 (8) :744-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1
Frequently Asked Questions
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