Thiamine disulfide

Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].

Product Specifications

CAS Number

[67-16-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; HIV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/thiamine-disulfide.html

Purity

99.54

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C/C(N(CC1=CN=C(C)N=C1N)C=O)=C(SS/C(CCO)=C(N(CC2=CN=C(C)N=C2N)C=O)\C)/CCO

Molecular Formula

C24H34N8O4S2

Molecular Weight

562.71

Precautions

H302, H315, H319, H335

References & Citations

[1]S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205 (1) :967-75.|[2]Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81 (8) :744-6.