Homo-PROTAC pVHL30 degrader 1

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.

Product Specifications

CAS Number

[2244684-49-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Homo-PROTAC_pVHL30_degrader_1.html

Purity

99.40

Solubility

DMSO : ≥ 150 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

CC1=C(C2=CC=C(CNC([C@@H]3C[C@@]([H])(O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

Molecular Formula

C58H82N8O14S2

Molecular Weight

1179.45

Precautions

H315, H319, H320

References & Citations

[1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8 (1) :830.