Homo-PROTAC pVHL30 degrader 1
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.
Product Specifications
CAS Number
2244684-49-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Homo-PROTAC_pVHL30_degrader_1.html
Purity
99.40
Solubility
DMSO : ≥ 150 mg/mL|H2O : 25 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC=C(CNC([C@@H]3C[C@@]([H])(O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1
Molecular Formula
C58H82N8O14S2
Molecular Weight
1179.45
Precautions
H315, H319, H320
References & Citations
[1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8 (1) :830.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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