Meranzin

Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) . Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2].

Product Specifications

CAS Number

[23971-42-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adrenergic Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/meranzin.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C=C2)C(OC2=O)=C1C[C@H](O3)C3(C)C

Molecular Formula

C15H16O4

Molecular Weight

260.29

Precautions

H315, H319, H335

References & Citations

[1]Lan Li, et al. Chaihu-Shugan-San and Absorbed Meranzin Hydrate Induce Anti-Atherosclerosis and Behavioral Improvements in High-Fat Diet ApoE -/- Mice via Anti-Inflammatory and BDNF-TrkB Pathway. Biomed Pharmacother. 2019 Jul;115:108893.|[2]Rongwei Yan, et al. Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography. J Sep Sci. 2018 May;41 (9) :2092-2101.