Ramosetron

Ramosetron (YM060 free base) is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron is promising for research of irritable bowel syndrome with diarrhea[1][2][3][4].

Product Specifications

CAS Number

[132036-88-5]

Product Name Alternative

YM060 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ramosetron.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1CC2=C(N=CN2)CC1)C3=CN(C)C4=CC=CC=C34

Molecular Formula

C17H17N3O

Molecular Weight

279.34

References & Citations

[1]Fukudo S, et al. Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women. Gastroenterology. 2016 Feb;150 (2) :358-66.e8. |[2]http://www.drugsupdate.com/generic/view/1111|[3]Yasuda M, et al. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol. 2013 Mar;168 (6) :1388-400.|[4]Kojima SI, et al. Investigation of 5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200.